The First of its kind. Fast, Fine-tuned and Flexible. Designed to help you navigate your solubility and aggregation problems.
Measuring solubility and aggregation is resource-intensive, slow and prone to error. Incomplete knowledge of solubility and aggregation profiling leads to high risk of clinical failure and costly iterations. The F1 is your Solubility Navigator and helps you overcome your solubility and aggregation challenges.
The F1 brings you the power of ultrafast femtosecond laser to probe your samples.
The light pulse illuminating your sample interacts with the liquid in a process called Second Harmonic Scattering
The femtosecond pulses allows F1 to probe the rearrangement of solvent molecules in the presence of aggregates, with nanomolar sensitivity in a non-destructive way. This is the Solvent Redistribution method.
The F1 reinvents Second Harmonic Scattering in a format dedicated to well-plates automation, for faster measurements.
With its simplified measurement process and automated analysis, it delivers results for a full 384 well-plate in 15 minutes.
ACCELERATING YOUR DECISION-MAKING.
The F1 brings you nanomolar sensitivity.
Thanks to the exquisite sensitivity of Second Harmonic Scattering to structural changes at molecular level, the F1 can measure even below micromolar concentrations.
PROVIDING YOU CUTTING-EDGE INSIGHTS ON WHAT IS TRULY HAPPENING IN YOUR SAMPLE.
The F1 requires minimal amount of resources. For maximal results.
With its well-plate based format and its non-destructive light scattering technology, the instrument only requires 50-300 μL of working volume per well and ~2 μL of stock solution (10 mM in DMSO, 100 μM max concentration) per solubility datapoint. In addition it preserves your sample for further orthogonal validation or kinetic studies.
BECAUSE IT IS SOMETIMES BEST TO ASK FOR THE LEAST.
By providing fast and reliable feedback with minimal resources, the F1 unlocks and accelerates your decision-making.
Finally understanding what works and doesn’t work in your sample brings clarity. The F1 helps you profiling the best conditions for your samples, and navigating through the best route for next steps of development.
PLANNING IN ADVANCE IS A SUPERPOWER.
The F1 is a flexible platform covering small and large molecules, across various experimental conditions.
By using a non-resonant scattering technique, the instrument can measure any molecule in a dipolar solvent.
VERSATILITY HAS A MULTIPLIER EFFECT ON YOUR RESEARCH.
From small molecules to big molecules
Across various experimental conditions
With its versatile capabilities, the F1 can guide you in your studies at different points of the pipeline
Key applications
Where in your pipeline
The F1 simplifies your workflow. No complex training, calibration, lengthy protocols, nor brain-twister data-processing.
With its automated screening and straightforward software analysis, the F1 gives you a direct answer without conundrum.
SOMETIMES, SIMPLE WORKS BEST.
Using less compound and chemicals is good for the environment but also your wallet. And preserving your precious research time.
ALLOWING YOU TO PUT MORE RESOURCES INTO WHAT MATTERS.
| Typical read time per 384 well-plate | 15 min |
| Working volume per well | 50-300 μL |
| Compound consumption | ~2 μL per solubility datapoint (10 mM DMSO, 100 μM max concentration) |
| Sensitivity | <1 μM, 10 Da to 1 Mda |
| Supported well-plates | 96/384 (COC film bottom) |
| Detection modes | Second harmonic scattering |
| Excitation wavelength | 1030 nm |
| Data Analysis | Automated solubility calculation incl. outlier detection |
| Data Export | Tables and graphs of raw data and analysis results |
| Dimensions WxHxD | 650x750x615 mm |
| Weight | 75 kg |
| Operating voltage | 100-240 V |
| Operating temperature | 15-28°C |
| Relative humidity | 30-80 % (non-condensing) |
